Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/244405089?client_source=feed&format=rss
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Friday, August 31, 2012
Thursday, August 30, 2012
New TGen, Virginia G. Piper Cancer Center study targets non-small cell lung cancer
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 29-Aug-2012[ | E-mail |
Share ] Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
PR610 designed to activate in cancer tissue with low levels of oxygen
SCOTTSDALE, Ariz. August 29, 2012 A Phase I/II, multi-center trial designed to test the safety and preliminary efficacy of a first in class cancer treatment opened worldwide today at the Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen). PR610 is designed to become activated in tissues with low levels of oxygen, which is characteristic of many cancers. This "targeted" approach should deliver more active drug to cancer tissue and less active drug to normal tissue.
The two-part trial, sponsored by the drug's manufacturer, Proacta Inc., will first determine acceptable dose levels of PR610 in patients with various types of advanced cancer. After determining acceptable dose levels, the study will evaluate the safety and efficacy of PR610 when given to patients with non-small cell lung cancer whose tumors contain a certain genetic mutation. Other goals of the study are to measure levels of PR610 in the blood.
"PR610 is a promising and innovative compound that merges delivery of a drug to the cancerous, oxygen depleted tissue and it also targets the communication functions that govern the growth and behavior that drive certain cancers," said Dr. Glen Weiss, Clinical Associate Professor at TGen and Director of Thoracic Oncology at Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare.
Research has shown that some cancer tissue has lower levels of oxygen than normal tissue. This lower level of oxygen appears to make the cancer tissue more resistant to radiation and chemotherapy, which allows the cancer to become more aggressive and spread. PR610 is designed to become active in cancer tissue with low levels of oxygen.
"Proacta is very excited to be working with Virginia G. Piper Cancer Center Clinical Trials and TGen on this important study. We purposely limited participation in this study to those cancer centers with extensive experience and expertise in conducting clinical oncology trials," said Dr. John Gutheil, CEO of Proacta.
Non-small cell lung cancer is a disease in which cancerous cells form in the tissues of the lung. There are several types, and chances of recovery are determined by many factors, such as smoking and lifestyle. Unfortunately, current treatments options do not cure the majority of patients with non-small cell lung cancer.
About 44 people will participate in this study at research sites in the U.S. and New Zealand, with the Virginia G. Piper Cancer Center at Scottsdale Healthcare being the first to enroll a patient.
###
About the Virginia G. Piper Cancer Center at Scottsdale Healthcare
The Virginia G. Piper Cancer Center at Scottsdale Healthcare opened in 2001 as the first major cancer center in greater Phoenix, offering comprehensive cancer care and research through Phase I clinical trials, diagnosis, treatment, prevention and support services in collaboration with leading researchers and community oncologists. The Scottsdale Healthcare cancer program holds Accreditation with Commendation from the Commission on Cancer of the American College of Surgeons. Scottsdale Healthcare is the nonprofit parent organization of the Virginia G. Piper Cancer Center at Scottsdale Healthcare, Scottsdale Healthcare Research Institute, Scottsdale Healthcare Osborn Medical Center, Scottsdale Healthcare Shea Medical Center and Scottsdale Healthcare Thompson Peak Hospital. For more information, visit www.shc.org.
Press Contact:
Jamie Houston
Public Relations Coordinator
Virginia G. Piper Cancer Center
480-323-1387
jhouston@shc.org
About TGen
The Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based non-profit organization dedicated to conducting groundbreaking research with life changing results. Research at TGen is focused on helping patients with diseases such as cancer, neurological disorders and diabetes. TGen is on the cutting edge of translational research where investigators are able to unravel the genetic components of common and complex diseases. Working with collaborators in the scientific and medical communities, TGen believes it can make a substantial contribution to the efficiency and effectiveness of the translational process. For more information, visit: www.tgen.org.
Press Contact:
Steve Yozwiak
TGen Senior Science Writer
602-343-8704
syozwiak@tgen.org
About Proacta Incorporated
Proacta is a San Diego based biotechnology company dedicated to the development and commercialization of hypoxia-activated oncology drugs. Proacta has a pipeline of hypoxia-activated prodrugs for the treatment of cancer that are licensed from the University of Auckland in New Zealand. For more information on Proacta, visit the Proacta web site at www.proacta.com
Proacta Incorporated:
John Gutheil, MD, CEO
858- 642-0386
jgutheil@proacta.com
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 29-Aug-2012[ | E-mail |
Share ] Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
PR610 designed to activate in cancer tissue with low levels of oxygen
SCOTTSDALE, Ariz. August 29, 2012 A Phase I/II, multi-center trial designed to test the safety and preliminary efficacy of a first in class cancer treatment opened worldwide today at the Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen). PR610 is designed to become activated in tissues with low levels of oxygen, which is characteristic of many cancers. This "targeted" approach should deliver more active drug to cancer tissue and less active drug to normal tissue.
The two-part trial, sponsored by the drug's manufacturer, Proacta Inc., will first determine acceptable dose levels of PR610 in patients with various types of advanced cancer. After determining acceptable dose levels, the study will evaluate the safety and efficacy of PR610 when given to patients with non-small cell lung cancer whose tumors contain a certain genetic mutation. Other goals of the study are to measure levels of PR610 in the blood.
"PR610 is a promising and innovative compound that merges delivery of a drug to the cancerous, oxygen depleted tissue and it also targets the communication functions that govern the growth and behavior that drive certain cancers," said Dr. Glen Weiss, Clinical Associate Professor at TGen and Director of Thoracic Oncology at Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare.
Research has shown that some cancer tissue has lower levels of oxygen than normal tissue. This lower level of oxygen appears to make the cancer tissue more resistant to radiation and chemotherapy, which allows the cancer to become more aggressive and spread. PR610 is designed to become active in cancer tissue with low levels of oxygen.
"Proacta is very excited to be working with Virginia G. Piper Cancer Center Clinical Trials and TGen on this important study. We purposely limited participation in this study to those cancer centers with extensive experience and expertise in conducting clinical oncology trials," said Dr. John Gutheil, CEO of Proacta.
Non-small cell lung cancer is a disease in which cancerous cells form in the tissues of the lung. There are several types, and chances of recovery are determined by many factors, such as smoking and lifestyle. Unfortunately, current treatments options do not cure the majority of patients with non-small cell lung cancer.
About 44 people will participate in this study at research sites in the U.S. and New Zealand, with the Virginia G. Piper Cancer Center at Scottsdale Healthcare being the first to enroll a patient.
###
About the Virginia G. Piper Cancer Center at Scottsdale Healthcare
The Virginia G. Piper Cancer Center at Scottsdale Healthcare opened in 2001 as the first major cancer center in greater Phoenix, offering comprehensive cancer care and research through Phase I clinical trials, diagnosis, treatment, prevention and support services in collaboration with leading researchers and community oncologists. The Scottsdale Healthcare cancer program holds Accreditation with Commendation from the Commission on Cancer of the American College of Surgeons. Scottsdale Healthcare is the nonprofit parent organization of the Virginia G. Piper Cancer Center at Scottsdale Healthcare, Scottsdale Healthcare Research Institute, Scottsdale Healthcare Osborn Medical Center, Scottsdale Healthcare Shea Medical Center and Scottsdale Healthcare Thompson Peak Hospital. For more information, visit www.shc.org.
Press Contact:
Jamie Houston
Public Relations Coordinator
Virginia G. Piper Cancer Center
480-323-1387
jhouston@shc.org
About TGen
The Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based non-profit organization dedicated to conducting groundbreaking research with life changing results. Research at TGen is focused on helping patients with diseases such as cancer, neurological disorders and diabetes. TGen is on the cutting edge of translational research where investigators are able to unravel the genetic components of common and complex diseases. Working with collaborators in the scientific and medical communities, TGen believes it can make a substantial contribution to the efficiency and effectiveness of the translational process. For more information, visit: www.tgen.org.
Press Contact:
Steve Yozwiak
TGen Senior Science Writer
602-343-8704
syozwiak@tgen.org
About Proacta Incorporated
Proacta is a San Diego based biotechnology company dedicated to the development and commercialization of hypoxia-activated oncology drugs. Proacta has a pipeline of hypoxia-activated prodrugs for the treatment of cancer that are licensed from the University of Auckland in New Zealand. For more information on Proacta, visit the Proacta web site at www.proacta.com
Proacta Incorporated:
John Gutheil, MD, CEO
858- 642-0386
jgutheil@proacta.com
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-08/ttgr-ntv082912.php
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Wednesday, August 29, 2012
The Sims 3 Pets Expansion [Mac Download] | Shopper Selections
Pinned on August 28, 2012 at 1:27 pm by Edgar Stone
Product Features
- Be the pet ? Wield control of your pets to chase, dig, tackle, and more. Be the perfect companion or wreak havoc on your Sims!
- Pets have their own traits ? From intelligent, friendly, and proud to playful, adventurous, and aggressive, determine the personalities of your Sims? pets.
- Pets can learn skills ? Cats and dogs can learn to hunt, dogs can learn to locate collectibles and fetch your Sims a date. With career opportunities, your Sims? pets can even work their way up the chain to become the ultimate criminal mastermind.
- More pets mean more fun! Create a wide variety of unique dogs, cats, and ? for the first time ever ? horses! Think your Sim has what it takes to tame a wild horse?
Comments
Source: http://shopperselections.com/2012/08/the-sims-3-pets-expansion-mac-download/
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Merging the biological and the electronic
Monday, August 27, 2012
Harvard scientists have, for the first, time created a type of "cyborg" tissue by embedding a three-dimensional network of functional, bio-compatible nanoscale wires into engineered human tissues.
As described in a paper published August 26 in Nature Materials, a multi-institutional research team led by Charles M. Lieber, the Mark Hyman, Jr. Professor of Chemistry at Harvard and Daniel Kohane, a Harvard Medical School professor in the Department of Anesthesia at Children's Hospital Boston developed a system for creating nanoscale "scaffolds" which could be seeded with cells which later grew into tissue.
Also contributing to the work were Robert Langer, from the Koch Institute at the Massachusetts Institute of Technology, and Zhigang Suo, the Allen E. and Marilyn M. Puckett Professor of Mechanics and Materials at Harvard's School of Engineering and Applied Sciences.
"The current methods we have for monitoring or interacting with living systems are limited," said Lieber. "We can use electrodes to measure activity in cells or tissue, but that damages them. With this technology, for the first time, we can work at the same scale as the unit of biological system without interrupting it. Ultimately, this is about merging tissue with electronics in a way that it becomes difficult to determine where the tissue ends and the electronics begin."
The research addresses a concern that has long been associated with work on bioengineered tissue ? how to create systems capable of sensing chemical or electrical changes in the tissue after it has been grown and implanted. The system might also represent a solution to researchers' struggles in developing methods to directly stimulate engineered tissues and measure cellular reactions.
"In the body, the autonomic nervous system keeps track of pH, chemistry, oxygen and other factors, and triggers responses as needed," Kohane explained. "We need to be able to mimic the kind of intrinsic feedback loops the body has evolved in order to maintain fine control at the cellular and tissue level."
Using the autonomic nervous system as inspiration, Bozhi Tian, a former doctoral student under Lieber and former postdoctoral fellow in the Kohane and Langer labs, and collaborator Jia Liu worked in Lieber's lab at Harvard to build mesh-like networks of nanoscale silicon wires?about 30 - 80 nm in diameter?shaped like flat planes or in a reticular conformation.
The process of building the networks, Lieber said, is similar to that used to etch microchips.
Beginning with a two-dimensional substrate, researchers laid out a mesh of organic polymer around nanoscale wires, which serve as the critical nanoscale sensing elements. Nanoscale electrodes, which connect the nanowire elements, were then built within the mesh to enable nanowire transistors to measure the activity in cells without damaging them. Once complete, the substrate was dissolved, leaving researchers with a net-like sponge or a mesh that can be folded or rolled into a host of three dimensional shapes.
Once complete, the networks were porous enough to allow the team to seed them with cells and encourage those cells to grow in 3D cultures.
"Previous efforts to create bioengineered sensing networks have focused on two-dimensional layouts, where culture cells grow on top of electronic components, or on conformal layouts where probes are placed on tissue surfaces," said Tian. "It is desirable to have an accurate picture of cellular behavior within the 3D structure of a tissue, and it is also important to have nanoscale probes to avoid disruption of either cellular or tissue architecture."
Using heart and nerve cells, the team successfully engineered tissues containing embedded nanoscale networks without affecting the cells' viability or activity. Using the embedded devices, they were able to detect electrical signals generated by cells deep within the tissue, and to measure changes in those signals in response to cardio- or neuro-stimulating drugs.
Researchers were also able to construct bioengineered blood vessels, and used the embedded technology to measure pH changes ? as would be seen in response to inflammation, ischemia and other biochemical or cellular environments ? both inside and outside the vessels.
Though a number of potential applications exist for the technology, the most near-term use, Lieber said, may come from the pharmaceutical industry, where researchers could use the technology to more precisely study how newly-developed drugs act in three dimensional tissues, rather than thin layers of cultured cells. The system might also one day be used to monitor changes inside the body and react accordingly, whether through electrical stimulation or the release of a drug.
###
Harvard University: http://www.harvard.edu
Thanks to Harvard University for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/122941/Merging_the_biological_and_the_electronic
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Tuesday, August 28, 2012
NASA's Restored Footage of Neil Armstrong's First Steps on the Moon
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Source: http://www.labspaces.net/122990/NASA_s_Restored_Footage_of_Neil_Armstrong_s_First_Steps_on_the_Moon
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Friday, August 24, 2012
Program Coordinator, Public Service (40) - HigherEdJobs
Job Summary/Responsibilities:
?I.Promotes the University as a site for meetings and conferences. Develops, plans,
organizes and implements the promotion of University services and facilities. These include promotion of conference management services,
meeting, housing, catering, dining, and related facilities and services to clients involved in educational pursuits and partnerships.
II. Develops innovative conferencing programs to promote Illinois State University faculty expertise in developing marketable meetings and conferences.
III. Implements Conference Services marketing/action plan and programs.
Required Qualifications:
I. Minimum of a bachelor's degree in a related field AND at least two years previous sales
and/or marketing experience, preferred in conference/meeting planning and development.
II. Hotel, convention bureau, catering, sales, event or meeting planning experience or equivalent skills as obtained through professional training programs.
III. Demonstrated experience in marketing programs and services; experience in conceptualizing, planning, coordinating and evaluating programs, services and events.
IV. Demonstrated experience in developing conference budgets and tracking expenses.
V. Excellent communications skills (verbal and written) required, with experience in interpreting policies and procedures.
VI. Ability to establish and maintain cooperative working relationships.
VII. Demonstrated organizational and analytical problem solving skills.
VIII. Management of multiple priorities and ability to proactively deal with quick changing priorities.
IX. Experience in data management, spreadsheet and registration software, especially Microsoft Word, Excel, Access, Powerpoint, and the ability to understand complex on-line systems.
Preferred Qualifications: The ability to work flexible hours, evenings and weekends as needed for conference facilitation and management. Vacations and time off may be limited during these time periods. Notice of these additional hours would be communicated well in advance.
Special Instructions: Please prepare in advance separate documents representing a resume, cover letter, and a list of at least (3) references to attach to this application.
Proposed Start Date: November 1, 2012
Salary: commensurate with experience
Illinois State University is an equal opportunity/affirmative action university encouraging diversity.
Source: http://www.higheredjobs.com/details.cfm?JobCode=175662222
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Thursday, August 23, 2012
Methods for Chronic Pain Management | Change For Life Weightloss
Neglecting chronic pain can bring trouble to your health and lifestyle. It can cause stress, anxiety and depression and thereby, affect personal, professional and social life by interfering with sleep patterns. There are various alternative methods for chronic pain management. Let us know what they are:
You need to choose the right doctor to alleviate your chronic pain. If the doctor you are visiting for years is not being able to provide you any effective solutions for your chronic pain, there is no point sticking to that professional. It is better to find the best professional who can give you permanent solutions. Also you should feel comfortable with the doctor you visit for treating chronic pain so that you can discuss with him about the important aspects of your health for proper treatment.
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Try to keep your life as normal as possible. You can fall prey to stress and depression if you cut off yourself from friends, family and relatives. Do take part in social activities as you may meet new people and explore new avenues that may pep up your mood and spirits. Therefore, accept invitations and engage yourself in interesting activities.
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An effective method for chronic pain management is starting an exercise program. Consult your doctor regarding which exercise methods are perfect for you. If you engage yourself in an exercise regimen daily, it will provide you with a lot of positive energy, alleviate pain and take care of your mental state.
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You need to prepare some practical goals for yourself to achieve every day. Creating and fulfilling goals that stimulate your spirits will make you feel motivated and satisfied. You can discuss about these objectives with your doctor to ensure that you are proceeding in the right path. He can guide you towards reaching goals at a right pace.
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The environment at your home should be congenial and loads of positivity. It should be like when you step inside your house, the environment welcomes you with positive energy. Share your feelings and problems with your family members. Spend some quality with them. They can turn out to be the solace to all your troubles. In short, surround yourself with positive people with whom you feel comfortable most.
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You should stop smoking, drinking alcohol and taking drugs. These are definitely not the ideal methods to get permanent solutions for a problem like chronic pain.
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Every person has certain limitations and strengths. While you are proud of your strong points, do not upset yourself with your minus points. You have to accept our limitations to make your life smooth and easy. With this you can check your chronic pain which is mostly caused by having problems in accepting the not-so-strong points.
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Visit a spa for rejuvenating your mind and body. Indulge in a luxurious body massage by a professional to reduce chronic joint pains. ?If you live in Palm Beach Gardens, make sure you hire an experienced Palm Beach Gardens massage therapist.
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Author Bio:Justin Brown is a fitness trainer and an instructor. He used to run a fitness training center in Massachusetts a year back, but now he is working as a nutritionist at a reputed firm. He specializes on alternative medicines, effective treatments like chiropractic, dietary supplements and organic food products. Justin has also been writing on Palm Beach Gardens pain management for quite some time.
Source: http://changeforlifeweightloss.com/methods-for-chronic-pain-management/
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How To Select The Right Roof Color For Your Home ? selaroofing
Color selection for any home improvement project can be both an exciting and stressful decision. For the best results, your new roof color should compliment the rest of your home?s exterior, including the siding or brick color as well as the associated trim. If you are unsure about shingle color, there are several methods to help ensure that you will be happy with your color decision:
- Look at houses similar to yours. Specifically look for houses with similar architecture and roof lines.
- Simulation Programs ? Many manufacturers and some contractors have access to computer simulation programs that can model various shingle types and roof colors on your house. While these programs are a useful tool for comparisons and narrowing choices, please remember the limitations in viewing colors on a computer monitor or printout.
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Source: http://blog.selaroofing.com/2012/08/23/how-to-select-the-right-roof-color-for-your-home/
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The LG Optimus S Cell Phone: A Well-Designed, Affordable - HostExe
For users wishing to experience a mobile phone that is both simple and powerful, the newly released LG Optimus S Cell Phone is sure to satisfy. Based on the Android operating system, the LG Optimus S offers smartphone functionality on a budget. Sprint adds to the appeal of this phone with its new Sprint ID service, an ID pack which allows users to personalize their handsets with typical smartphone options they?ve come to expect: including widgets, wallpapers, ringtones and applications. At a cost of only .99 (with a 2 year service plan and 0 rebate), the Optimus S is available in any local Sprint outlet.
Boasting a 600 MHz processor running Android 2.2 Froyo, the LG Optimus S Cell Phone comes equipped with a 3.2 megapixel camera with autofocus. A hefty and slim, solid phone, the Optimus features a 3.2-inch capacitive touchscreen, an FM radio, a virtual QWERTY keyboard, and even a global positioning system (GPS).
It?s outfitted with a microSD slot that is expandable up to 32 GB; visual voicemail, for more personal and informative asynchronous communications; a Mobile Hotspot capability supporting up to 5 Wi-Fi enabled devices, that allows tethering, as well as simultaneous, 3G quality data sharing; this permits the connecting of other personal computing devices such as laptops, game players and cameras for fast, 3G connection speed anywhere on the Sprint 3G network. However this feature comes with an additional charges. The phone also features Bluetooth for wireless data transfer or earpiece communication.
On the down side, the LG Optimus S Cell Phone?s slower processor does prohibit the use of Flash video in the browser; nor does it offer HD video capture or an LED flash for the camera.
Users report a very quick and responsive screen and terrific keyboard ergonomics. Small, compact, yet solid, sleek and grippable, this phone overcomes its drawbacks for being a newer model with fewer available accessories.
The Sprint Free Guarantee provides a full money-back guarantee on the LG Optimus S Cell Phone. Customers who aren?t satisfied can return their phone device and cancel their service plan. This plan refunds all money saved for usage, premium content, 3rd party billing, or international charges. They also reimburse for purchase and activation, with no early termination or restocking charges, including tax.
Ehtisham Rabbani, the corporate vice president of Marketing and Innovation for LG Mobile Phones, says, ?LG Optimus S brings users closer to social networks, applications and online resources that mean the most to them and creates a smartphone experience that is unique, easy to navigate and convenient for life on-the-go.? Its chic, slim design, and rapid, convenient downloads of personalized ID packs are sure to be a hit with consumers.
Add to this affordable pricing and wifi sharing capability, and the Sprint marketplace is sure to remain a fresh resource for technical and basic users. The LG Optimus S Cell Phone can be personalized to fit lifestyles from sports fanatics to fitness or auto enthusiasts; users can quickly shift between English and Spanish. This phone is well designed and a good-looking performer for a reasonable price.
For more information on cell phones visit?http://freesms.com.
?
Source: http://hostexe.org/the-lg-optimus-s-cell-phone-a-well-designed-affordable-smartphone
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Wednesday, August 22, 2012
Deciding On The Right Football Team Uniforms
Anyone that is tasked without the strategy of training a sports team is normally called for to make a multitude of decisions and kind via a number of choices. This is a base of decision making that is concentrated on making certain the whole grouping of participants has what they have to effectively bet the video game. Coaches that are experiencing this component of the planning and buying strategy must be capable of picking the best football team uniforms for their members.
The components that are used to produce the clothes items really should additionally be looked over. These are apparel items that are likely to withstand a substantial volume of misuse as well as wear as well as tear which demands a product base that is tough and also lengthy enduring. This is valuable in ensuring that any sort of item acquired is qualified of lasting the whole period.
Soccer is actually a very popular and also frequently participated in sporting occasion amongst sports aficionados globally today. This is just one of the sports where intelligence and also endurance are required to mixture together for a successful game to be played. The majority of sports need some type of garments to be used which is viewed throughout the usage of youth basketball uniforms and some other kinds of items for various occasions.
Coaches seeking team sports jerseys and also some other products to use while playing have numerous options to pick from. These are normally selections that are hard to sort via as they are often comparable from one service provider to an additional. Making this choice much easier is carried out be keeping a number of factors to consider in mind.
The colours that are appointed to the true team must constantly be thought of in this procedure. Each grouping of players within any online game is denoted by particular colors that are predetermined which is frequently linked to a wardrobe that is worn. This is normally one of the simplest features of this entire option.
The components that are used to produce the clothes items really should additionally be looked over. These are apparel items that are likely to withstand a substantial volume of misuse as well as wear as well as tear which demands a product base that is tough and also lengthy enduring. This is valuable in ensuring that any sort of item acquired is qualified of lasting the whole period.
A lot of coaches even focus on the variety of sizing possibilities that are readily available to all users. There are numerous examples where participants are extensively ranged in measurements which really should all have the ability to identify the most suitable fitting clothes items possible when wagering. This is usually an incredibly typical providing and also ought to be a major aspect in any kind of decision making attempt.
At last, the best football team uniforms are those that are cost effective. The prices charged are demanded to be paid by each player which can easily be tough for them to come up with. Keeping these products reasonable in fee makes certain that each player has the items they require.
Source: http://www.artipot.com/articles/1344873/deciding-on-the-right-football-team-uniforms.htm
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Ovulation spurred by newfound semen ingredient
Growth-boosting protein may act as pregnancy-protecting hormone in humans
Web edition : Monday, August 20th, 2012
Semen doesn?t just ferry sperm. It also bears a mystery ingredient that turns on ovulation in some animals and may even pump up fertility in humans as well. The molecule, nerve growth factor, kick-starts egg release and revs up pregnancy-protective hormones in llamas, researchers report online August 20 in the Proceedings of the National Academy of Sciences. Llama semen is loaded with NGF, says study coauthor and veterinarian Gregg Adams of the University of Saskatchewan in Saskatoon, Canada. The protein is also found in the semen of bulls and humans.
"If we find that NGF is also effective in women, it will obviously have huge implications for treating male infertility conditions,? says reproductive biologist Raj Duggavathi of McGill University?s campus in Sainte-Anne-de-Bellevue, Canada. ?It could be a big boost for couples.
NGF is well-known to biologists but not in the context of reproduction. Nerve cells typically spit the protein out to tell neighboring cells to grow.
Previous findings that semen could trigger ovulation in llamas challenged conventional wisdom that the physical movements of sex were what stimulated egg drop in the animals, says Adams. Unlike humans cows, horses and sheep, which ovulate on a regular cycle, some animals rely on a little action to get their eggs moving.
Adams? team had shown that semen ? filtered free of sperm ? injected into llamas? leg muscles could set off ovulation all on its own ? no bump-and-grind required. Semen from stallions, cattle, boars and rabbits could also prod llamas to ovulate.
What?s more, in llamas and other animals, the seminal substance nurtured growth of a little yellow gland in the ovary called the corpus luteum. The gland churns out hormones essential for maintaining a pregnancy. Humans rely on it early in gestation, before the placenta plumps up and takes over. A fizzled-out corpus luteum with low-flowing hormones can make women miscarry.
Adams? team has known since 2005 that some ingredient in llama semen juices up ovulation, but until now, they didn?t know what it was.
To pinpoint NGF?s identity, Adams? group first collected semen from five llamas. Next, researchers filtered out the sperm, then zeroed in on the special semen substance by injecting increasingly pure portions into female llamas? legs. Next, Adam?s team followed a step-by-step process to rule out potential molecular suspects.
The molecule?s size, structure and biochemical properties clued researchers in to its identity. ?Through a process of elimination, we finally realized it was a very hearty, very tough protein. When we found out that it was NGF, we scratched our heads and said, ?That?s strange ? NGF isn?t supposed to work this way,?? Adams says. Instead of signaling nearby cells, semen NGF goes all the way through the blood vessels to the brain, where it delivers the message to get busy cranking out more hormones.
Adams? team confirmed that the llama semen substance was NGF by using a technique usually seen in fertility clinics: injections followed by ultrasounds. The researchers gave llamas shots of either the purified semen substance or NGF from mouse salivary glands ? a classic source of the protein. Then, they checked the animals? reproductive organs with daily ultrasounds. Both substances made ovulation rates shoot up.
I?m fairly convinced? that NGF is the ovulation-sparking semen substance, says reproductive biologist Bruce Murphy of the University of Montreal. ?It?s a blockbuster paper,? he says. The work is the first to link NGF to reproductive function.
Next, Adams? team plans to investigate NGF?s role in human semen ? to see if it?s connected to fertility in people as well as llamas. Because women, unlike llamas, don?t need semen to ovulate, it?s not clear yet if NGF is also important for people, says reproductive biologist Dan Bernard of McGill University in Montreal. ?It?s still early.? But, he says, ?I think the fact that they?ve identified the protein will put this work on the map.? The findings should provide fertile ground for other researchers in the field.
Even though human females ovulate regularly, sometimes women?s bodies gear up for egg release at odd times during their cycle. ?I want to know what happens if seminal plasma is absorbed at that time,? Adams says. ?Will it cause ovulation?? If a timely dose of semen does nudge an egg?s release, he says, ?It could be why we sometimes call couples who practice the rhythm method parents.?
In addition to tweaking ovulation timing, NGF could boost growth of the pregnancy-protecting corpus luteum in humans. If NGF can cultivate the gland the way it does in llamas, cattle, and mice, it?s possible that frequent sex ? and thus a steady supply of semen ? during early pregnancy could help prevent miscarriage.
The idea ?is not crazy at all,? Adams says.
Found in: Body & Brain
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Tuesday, August 21, 2012
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Source: http://businessmarketinga-z.blogspot.com/2012/08/medical-transcribing-as-well-as-gps.html
The Creatives: Kevin and Caroline of Corner Store ? We Love Perth
We?ve long been wanting to interview the team behind the amazing mini empire that is Store / Corner Store, and it?s finally happened! Meet Kevin and Caroline, two of the owners of the gorgeous homewares, gift and furniture shops ? or for want of a better word, ?lifestyle shops?. Interviewing these two is really like talking to retail royalty! Kevin and Caroline have had a number of clothing, homewares and shoe stores over the years, and at one stage probably made up a large part of the market of trendy Perth stores. Now they?re threatening to do it all over again with the beautiful Store and Corner Store concepts popping up all over town, and really, we couldn?t be more delighted!
We love a family business! Who is behind Corner Store?
So do we! There?s Kevin and Caroline, Annie and Adam (Caroline?s brother) and all our wonderful staff.
Do you think family and business mix well?
We have to say yes, the other two might read this! But truthfully it?s great. We have our moments but when you are bound together by more important things in life it makes business a breeze.
What are each of your strengths in the business?
Caroline and Annie do the buying, merchandising and the general running of the day to day shop floor stuff. Kevin does the accounts, wages etc and works creatively with Kylie, whilst Adam is ?logistics?, organising furniture deliveries, manufacturing as well as head barista. Having said that the lines are often blurred as there is much crossover.
Inside Store, one of their Fremantle shops.
My early teens were spent browsing the second hand threads in Lush, when my niece was born I gushed over the baby toys in Store, and presently I?m swooning over the furniture in your showrooms, daydreaming about filling my house with the pieces. You?ve been a force of style in my life for the best part of 2 decades! Can you tell us a bit about the history of your retail stores and what permutations of stores you?ve been through?
Oh my! That does make us feel old! But it has been a progression in our lives too.
Lush started in 1992 as a market stall in the cultural centre when Caroline made clothes and sold them. We mixed in vintage clothes and opened our first shop on Cantonment Street Fremantle in ?94. Lush turned to Lick in ?96. After many trips to Europe gathering vintage clothing and ephemera we noticed a move to ?lifestyle? shops where all needs were met. We thought we?d have a go and with Annie and Adam set up Store in ?99 on Market Street just after the arrival of our first borns which tied in nicely with our stock mix too.
The Lush market stall at the Perth Cultural Centre back in 1993.
Lick moved in next to Store in 2001, which was a busy year as we opened up Wanderlust Footwear on Cantonment St with our friend Sarah Wallwork. We had quite a nice little triangle going on there for a while. Store Claremont opened in 2005 on St Quentin Ave, followed by Mount Lawley in 2008 which also saw the birth of Corner Store on Stirling Highway Claremont and the death of Store on St Quentin at the hands of a Hawaiian/Multiplex wrecking ball.
Last year it seemed like all we did was renovate. The original Store moved next door into the lovely old Lick shop and after months of throwing white paint around, Corner Store on South Terrace opened in October? I feel like a lie down now!
The different stores through the years ? Lick Clothing in 1996 (top); Store in 1999 (middle); and Wanderlust in 2001 (bottom).
How do you keep it so fresh over the years?
Tupperware!
What is the best thing about your job?
It?s not a job!
Take us through a typical day of your work:
The days vary but generally we start very early to get ahead before we get caught up in normal family life: preparing breakfasts, lunches and school runs. Once that?s done we then do our rounds of the shops, dropping off stock, making deliveries to customers, catch up with our staff and just general grown up business stuff. We then have a period after school pick ups where we work from home but we don?t really have that Work/Home separation as it?s so much a part of our lives!
What have been the hardest hurdles to face over the years in the retail biz?
I remember once the CD player broke and I had to sing to every customer that came in, people can be so cruel? That was a tough day.
Which local creatives do you admire?
Kylie Thevenau, our brilliant designer and ?family? member who embodies our style and ethos so well. And you two too!
The current Corner Store with beautiful window displays by Kylie Thevenau.
Any tips for those hoping to open a shop of their own?
Don?t!
Well, don?t spend too much on the fit-out ? white paint covers a multitude of sins. So many businesses have folded after investing so much money on the shell ? it?s all about what you are selling. It?s a bit like divorcing after an elaborate wedding. Keep it simple.
Their latest venture opened last year ? a white and bright Corner Store on South Terrace, Fremantle.
Plenty more pics over here.
What do you love about Perth?
Home and family.
What does Perth need?
The baby boomers to move aside and let the X?ers and Y?s have a go.
Most frequented coffee spot?
Cimablino in Cottesloe as well as Adam?s brew in our South Terrace showroom.
Best live music venue?
If I still went out I think I?d really like The Bird on William Street.
Favourite beach?
Echo Beach (far away in time).
Rottnest or Margaret River?
Rottnest, I love those big rabbits. Kevin & Caroline.
Thank you!!
If you?re looking to pretty up your place then be sure to check out the Store and Corner Store shops. Store (their gift/homewares shop) is located at 25 Market Street Fremantle, and 649F Alexander Building, Beaufort Street in Mount Lawley. Corner Store (their furniture/homewares showrooms) are located at 147 South Terrace Fremantle, and 201-205 Stirling Highway (Corner of Loch Street) Claremont. Otherwise for a bit of online shopping, blog reading, or just generally drooling over a lot of super pretty things head over to cornerstore.net.au.
Source: http://weloveperth.net.au/the-creatives-kevin-and-caroline-of-corner-store/
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Y Combinator-Backed Profig Launches An Affordable, Feature-Rich Instant Phone System
Profig, a new Y Combinator-backed startup, just launched its instant virtual phone system for small and medium businesses. The service is geared toward companies and individuals looking for a professional phone solution without the cost and hassle of using legacy hardware and software solutions. For just $30 per month, Profig offers its users one toll-free number, two local numbers, 500 minutes of calling time and 250 text messages. To celebrate its launch, the company is offering the first 1,000 new users who use 'techcrunch' as their discount code when they sign up a $30 credit (enough for one month of basic service) to test Profig.Source: http://feedproxy.google.com/~r/Techcrunch/~3/P6EvZvQtGwE/
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Monday, August 20, 2012
PHOTOS: Lea Michele & Cory Monteith Work the Red Carpet!
The Glee costars turn heads at the Do Something Awards! Check out more pics of Hollywood's tightest twosomes
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Fitness Keys consultants can help you with weight loss and physical ...
Fitness Keys consultants specializes in educating individuals on what they need to do in order to become physically fit. Send Feedback to FitnessKeys4U .com
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There are many ways to get into shape. Some people run others do aerobics at home. But there is no one method or technique that will lead you to fitness. The truth is diet, exercise, and general life style are all part of what it takes to stay fit and healthy. At Fitness Keys consultants, we help you discover this simple truth for yourself. We specialize in educating individuals on what they need to do in order to become physically fit.
Trying to work out, eat right, and maintain mental balance is difficult. With the shifting burdens of work and the time you need to dedicate to family, it can seem almost impossible to actually live a well-balanced life. And not everyone has the luxury of going to the gym or being serviced by a professional trainer. It is therefore necessary for busy people who want to stay in shape to acquire the knowledge themselves, so that they can apply it in a more flexible way.
Fitness Keys consultants aim to give you the tools you need to build your own fitness regimen and practice. You can get into the best shape of your life by using the tools of a program that will take you from strength to strength in both the bodily and spiritual realms. If you are a busy professional, you may not necessarily have time to for a daily work out. That is okay. Losing weight and getting fit include more than just hitting the gym everyday! At Fitness Keys consultants, we help you understand how you can shape your overall lifestyle to meet your weight loss and physical fitness goals.
It has never been more important to look after your health through fitness. We are all well aware of the obesity crisis in America and the part that unhealthy eating has played in it. However, eating habits are only part of what contributes to weight gain and unhealthiness. Stress and the sedentary nature of most of our jobs are also partly to blame for why so many of us find it difficult to manage our weight. The problem is as much social and economic as it is individual. But since none of us can do anything about the nature of work and business we must focus on our individual lives.
You don't have to live with the knowledge that you are not in good health. Getting fit will help you not only look good but also feel good. Indeed, getting in shape can be helpful to all aspects of your life, including work. If you are feeling run down at the end of the day or even by mid-afternoon, getting into an exercise routine can help. Shedding those extra pounds and getting your blood circulation up can give you the energy you need to get through the day and night.
Enjoying life to the fullest should be the aim of everyone who is happy and successful. Now you can ensure you're able to do so by developing the physical stamina that such a life requires.
About the Submitter
If you are looking to get physically fit, then Fitness Keys can help you do so--by just telling you the truth! For more information please visit: http://www.fitnesskeys4u.com
Contact:FitnessKeys4U .com
hakinsbrown@ymail.com
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Sunday, August 19, 2012
iPad 2 CDMA front panel
Just replaced my panel, instructions to take panel off were ok but...There are some steps that need to be included in the reassembly namely:
1.) Simple instructions to reattach button and front camera bracket. A picture is worth a thousand words, I was not sure if I had the button rotated in the right direction.
2.) Correct order to replace parts: I pulled out the LCD to clean up some broke glass. With the display out I affixed the adhesive strips only to discover I had to remove the corners to get to the screws.
3.) Adhesive strips: there needs to be a step showing were all the various strips go. Additionally they are backwards (in my opinion) if you want to adhere them to the body you have to first pull both sides of the adhesive off. It would be nice if they were flipped over on the paper but I know this is an OEM product and not your fault. A caution note would have saved me a few f-bombs.
Dave
Source: http://meta.ifixit.com/Answers/View/3634/iPad+2+CDMA+front+panel
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Romney slams Obama over Medicare
By Ian Johnston, NBC News, and wire services
Mitt Romney attacked President Barack Obama Saturday over the future of Medicare in his first weekly podcast ahead of the November election.
In the address posted on his website, the GOP's presidential candidate said Obama?s healthcare law had taken $716 billion from the fund to finance ?his takeover of the healthcare system.?
?Now if that wasn?t bad enough, his healthcare law also put in place a board of 15 unelected bureaucrats and gave them the power to make additional cuts to Medicare without even having to get approval from Congress,? he said.
?This means they could deny elderly Americans the care they?ve worked for their entire lives -- all because President Obama trusts bureaucrats more than he trusts seniors and their doctors,? he said.
?And here?s one more troubling aspect of all this: According to independent, non-partisan scorekeepers, these cuts the President?s people will take to Medicare won?t prevent it from going bankrupt: Experts estimate that Medicare?s trust funds will be exhausted just twelve short years from now,? Romney added.
The Democrats charge that Mitt Romney and Ryan would gut programs for older Americans such as Medicare and Social Security.?
Obama plans to dig in on that point in New Hampshire on Saturday with stops in Windham and Rochester. Aides say he will cast voters' choice as one between two very different approaches to government, The Associated Press reported.
The Obama campaign has claimed Romney's running mate Paul Ryan was forced to "flip flop" on Medicare by the GOP candidate. And Rep. Chris Van Hollen (D-MD) said the Romney-Ryan plan would "hasten the insolvency of the Medicare program by 8 years, that's according to the Medicare trustees."
Obama campaign says Ryan forced to flip flop on Medicare
On the campaign trail this week, Romney said the?Romney-Ryan plan to transform Medicare was "very similar" to Medicare Advantage.
But?Marsha Gold, a health-care expert at Mathematica Policy Research, said the big difference between the two is this: Medicare Advantage, like Medicare, is a defined benefit -- where the government guarantees a level of coverage -- while the Romney-Ryan plan transforms Medicare into a defined contribution -- where the government decides what it will pay.
Medicare Advantage vs. the Romney-Ryan plan
In the podcast Saturday, Romney reiterated a pledge to repeal ?Obamacare? ? that he characterized as ?threatening seniors? and ?a maze of new federal mandates, and taxes, and penalties that?s hampering job creation? ? and work on ?real solutions to save Medicare.?
Romney added that the plan would not change Medicare for those who are retired or ?near? retirement.
Campaign 2012 descends into trench warfare
For ?younger Americans,? he said future retirees would be provided with federal financial support and would be able to choose from a list of Medicare-approved coverage plans, including a traditional Medicare option.
?The amount of financial support that a person would get would be adjusted based on their income; more help would go to the poor or the sick -- and less help would go to those that are financially better off,? Romney added.
?It would be based on how much the plans cost so that seniors always have access to affordable, quality coverage. And no senior could ever be denied coverage for any reason,? he said.
The Associated Press contributed to this report.
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Tenor or bass section leader - First Church in Wenham, MA
Date: August 18, 2012
Seeking tenor or bass section leader, rehearsals Thurs 7-8:30p, most Sundays Sept-June. First Church in Wenham, 1 Arbor St., Wenham, MA. Paid per call. Solo opportunities as well! Perfect for strong student singer on the North Shore. Not far from Hamilton-Wenham Commuter Rail stop. Please contact Abby at frostabby@yahoo.com. Abigail Frost Conductor/Educator First Church in Wenham Hamilton-Wenham Regional School District
?
Source: http://www.choralnet.org/view/393971
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Saturday, August 18, 2012
PFT: 'Don't ever question my toughness,' Kolb says
Getty ImagesThe Jets are still thinking about the day that the defense had 99 problems and the ability to tackle Victor Cruz wasn?t one.
Dolphins WR Roberto Wallace, despite starting on Friday night, lived up to his ?Ankle Weights? nickname when trying to get separation.
Bills WR Donald Jones may have gotten some separation from T.J. Graham and Derek Hagan for the No. 2 spot on the depth chart.
Former Pats CB Ty Law thinks that the team?s current corners need to ignore what people are saying in order to develop the right kind of swagger.
Ravens RB Ray Rice is tired of simply making it to the playoffs.
When the Bengals cut WR Jordan Shipley, QB Andy Dalton saw a close friend waived for the first time.
Browns QB Brandon Weeden wants WR Josh Gordon to run cleaner routes.
Steelers QB Jerrod Johnson, who played the full second half of the preseason opener, could get even more reps against the Colts on Sunday night.
Texans coach Gark Kubiak sees a lot of himself in rookie QB Case Keenum (except, as Kubiak points out, he?s taller than Keenum).
The Jaguars haven?t said whether LT Eugene Monroe has a concussion.? (Maybe he simply has ?concussion-like symptoms.?)
Colts P Pat McAfee, who also kicked at West Virginia, broke out the boom stick for a 58-yard field goal in practice on Friday.
After another slow start on Friday night, Titans RB Chris Johnson began to look like his old self.
Chiefs WR Dwayne Bowe immediately passed his conditioning test upon signing his franchise tender and joining the team.
Between catching passes from QB Peyton Manning and running routes against CB Champ Bailey, WR Eric Decker could be on his way to stardom.
Raiders CB Ron Bartell says his team has the best defensive line in the league.? (Kevin Kolb hopes that?s the truth.)
Chargers QB Charlie Whitehurst will see his first game action since re-signing with the team after two seasons in Seattle.
Eagles RB Chris Polk could be moving to fullback.
Giants C Kevin Baas is feeling more comfortable in his second season with the team.
Cowboys CB Morris Claiborne says he?ll ?play the whole game? tonight against the Chargers if the coaches allow it.? (He likely says that in part because he knows they?ll never allow it.)
After looking good in training camp, Redskins WR Anthony Armstrong is hoping to rebound from a shoulder injury and make an impact in the team?s second preseason game.
Former Bears offensive coordinator Mike Martz says LT J?Marcus Webb will get better if he gets more confident.
The Packers will make a decision on QB Graham Harrell based on all four preseason games.? (The most recent of those preseason games resulted in a passer rating of 26.4.)
Lions coach Jim Schwartz says the team needs ?better players? on special teams; ?You can do all the drills you want, but if a guy can?t make a play, he can?t make a play,? Schwartz said.? ?We got to find guys who can kickoff cover and punt cover.? We were poor in those areas.?
Vikings RB Toby Gerhart looks the part as a starting tailback, even if his role is temporary.
Bucs LT Donald Penn is expected to resume practicing on Monday.
Saints fans recently served as guinea pigs for a test of the honor system.
The Panthers? offensive line looked much better in the second preseason game.? (Of course, that may have something to do with the fact that the Dolphins? front seven isn?t as good as the Texans? front seven.)
The Falcons view Jacquizz Rodgers as a three-down tailback.? (Michael Turner wants an explanation.)
Six days after a 38-3 loss to the Colts, Rams coach Jeff Fisher has a simple goal for tonight?s preseason game against the Chiefs:? Get better in every area.
Cardinals RB Ryan Williams was anxious to make his return to the field on Friday night; ?I can?t even lie, I was so nervous,? Williams said. ?I felt like I was six years old again playing Pop Warner.?
Seahawks LT Russell Okung has had a quiet camp, and he is happy about that.
49ers WR Ted Ginn is happy he can put the ?Jr.? on the back of his jersey, something that he has wanted to do ?for a long time? ? and that RG3 had the juice to persuade the league to allow.
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Pauls Valley 2012 Ford F-350 New Truck Norman Oklahoma City Seth Wadley Ford for $59,750
- Oxford White
- Beige
- CEC54517
- 6.7L V8, Diesel
- 1FT8W3DT2CEC54517
- Automatic 6-Speed
- 4 mi.
- 4WD Truck (4 Door Crew Cab)
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Interior
- Leather seats
- Split-bench rear seats
- Split-bench rear seats
- 8-way power adjustable drivers seat
- 8-way power adjustable passenger seat
Convenience
- Compass
- Bluetooth
- Tachometer
- Tachometer
- Trip computer
- Cruise control
- Power steering
- Power steering
- Power door locks
- AC power outlet - 1
- Power heated mirrors
- Clock - In-radio display
- Clock - In-radio display
- Power retractable mirrors
- Adjustable pedals - Power
- External temperature display
- External temperature display
- Power windows with 1 one-touch
- Video Monitor Location - Front
- Audio controls on steering wheel
- Tilt and telescopic steering wheel
- Tilt and telescopic steering wheel
- Air conditioning with dual zone climate control
Technical
- 4 Doors
- 4 Doors
- Four-wheel drive
- Four-wheel drive
- Dual Rear Wheels
- Dual rear wheels
- Dual Rear Wheels
- Dual rear wheels
- 6.7 liter V8 engine
- Bed Length - 98.0 "
- Bed Length - 98.0 "
- 4WD Type - Part-time
- 4WD Type - Part-time
- Automatic Transmission
- Automatic Transmission
- Transmission hill holder
- Transmission hill holder
Safety
- Passenger Airbag
- Passenger Airbag
- 4-wheel ABS brakes
- 4-wheel ABS brakes
- Dusk sensing headlights
- Front fog/driving lights
- Traction control - Driveline
- Traction control - Driveline
- Head airbags - Curtain 1st and 2nd row
- Head airbags - Curtain 1st and 2nd row
- Signal mirrors - Turn signal in mirrors
Exterior
- Trailer hitch
- Engine hour meter
- Engine hour meter
- Privacy/tinted glass
- Privacy/tinted glass
- Pickup Bed Type - Regular
- Intermittent window wipers
- Intermittent window wipers
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Payment $1,047.61 |
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*The advertised price does not include sales tax, vehicle registration fees, finance charges, documentation charges, and any other fees required by law. We attempt to update this inventory on a regular basis. However, there can be lag time between the sale of a vehicle and the update of the inventory.
EPA mileage estimates are for newly manufactured vehicles only. Your actual mileage will vary depending on how you drive and maintain your vehicle.
Before purchasing this vehicle, it is your responsibility to address any and all differences between information on this website and the actual vehicle specifications and/or any warranties offered prior to the sale of this vehicle. Vehicle data on this website is compiled from publicly available sources believed by the publisher to be reliable. Vehicle data is subject to change without notice. The publisher assumes no responsibility for errors and/or omissions in this data the compilation of this data and makes no representations express or implied to any actual or prospective purchaser of the vehicle as to the condition of the vehicle, vehicle specifications, ownership, vehicle history, equipment/accessories, price or warranties. 2012 Ford Oklahoma City, OK 2012 Ford Norman, OK 2012 Ford Pauls Valley, OK
Source: http://sethwadleyauto.com/2012-Ford-F-350-Pauls-Valley/vd/11339355
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